DNA From Structure To Function (BIO-0190)

Fall 2024 · BIO 0190 · Tufts University · 3 credits · Undergraduate

DNA is the indispensable molecule of life. Fundamentals of DNA structure and functioning are therefore central to understanding molecular genetics and genomics. In this course, DNA structure and function are examined through lectures and discussions of the original scholarly literature. Originally, DNA was believed to be a uniform right-handed double helix with limited structural flexibility. It has now become clear, however, that its structure is highly versatile, and this versatility is vital for major genetic processes. Topics include DNA secondary and tertiary structures, DNA topology and topoisomerases, mechanisms of protein-DNA recognition and the structure of the chromatin; how the principles of DNA organization are employed in key genetic transactions, including DNA replication, transcription, repair, and recombination. Recommendations: BIO 41 and junior standing or consent.

Course codes: BIO-0190, BIO 0190, BIO0190, BIO-190, BIO 190, BIO190

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